About ORTRD

Understanding the mechanisms governing gene expression control and expression heterogeneity requires an understanding of gene regulatory networks. Gene regulatory networks (GRNs) are responsible for encoding cell identity, whereby several transcription factors (TFs) binds to promoters and enhancers to control the expression of specific genes.

ORTRD is the most comprehensive database about gene regulation and gene expression in human olfactory receptors founded in 2024. ORTRD collates information from different resources. It includes manually curated olfactory receptor genes with its unique collection of TFs. ORTRD is a freely accessible and user-friendly database for exploring and visualizing the predicted regulatory networks formed by TFs and downstream target genes based on large-scale RNA-Seq data as well as the known TF-Gene relationships for various human olfactory receptors genes based on ChIP-Seq data.

All of the regulations in ORTRD are not determined experimentally; rather, they are anticipated based on the omics data. Users can search, browse, and download the TF-Gene pair information. We will continue to update ORTRD and add more datasets for Homo sapiens olfactory receptors.